He threw Gwen Stacy off the George Washington Bridge, masterminded the Clone Saga, went after Aunt May, and tried to kill Spider-Man every chance he got.

Source: https://www.cbr.com/surprising-team-ups-marvel-comics/

It was Gerry Conway who made Mary Jane the main love interest for Peter Parker (in part by, you know, killing off Gwen Stacy).

Source: https://www.cbr.com/spider-man-peter-parker-personal-life-stan-lee-steve-ditko/

One of the most impactful moments has ever had to face was when the Green Goblin killed his girlfriend, Gwen Stacy.

Source: https://collider.com/gwen-stacy-funko-pop-image/

While Bryce Dallas Howard’s natural red hair has been a glowing quality to her, her blonde hair that she dyed to play Gwen Stacy was on point.

Source: https://www.cinemablend.com/superheroes/spider-man/since-its-spider-man-week-bryce-dallas-howard-threw-back-to-her-blonde-gwen-stacy-era

While fans have long desired Emma Stone to portray a live-action Spider-Woman Gwen Stacy, Gwen's voice actress — Hailee Steinfeld — could also play the live-action version of the hero.

Source: https://screenrant.com/spider-man-across-the-spider-verse-emma-stone-gwen-stacy-art/